Phytoestrogens and Breast Cancer Prevention: Possible Mechanisms of Action

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Phytoestrogens and Breast Cancer Prevention: Possible Mechanisms of Action

OBJECTIVE Phytoestrogens display an array of pharmacologic properties, and in recent years investigation of their potential as anticancer agents has increased dramatically. In this article we review the published literature related to phytoestrogens and breast cancer as well as suggest the possible mechanisms that may underlie the relationship between phytoestrogens and breast cancer. DATA SO...

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Breast cancer: mechanisms involved in action of phytoestrogens and epigenetic changes.

In this review, we consider phytoestrogens and different epigenetic modifications in breast cancer. Epigenetic phenomena are mediated by several molecular mechanisms comprising histone modifications, small non-coding or anti-sense RNA and DNA methylation. These different modifications are closely interrelated. De-regulation of gene expression is a hallmark of cancer. Although genetic lesions ha...

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Phytoestrogens and Breast Cancer

Numerous epidemiological studies suggest that diets rich in phytoestrogens (PE), particularly soy and unrefined grain products, may be associated with low risk of some cancers, especially steroid hormone-dependent, e.g. breast and prostate cancers. Epidemiological, in vitro, animal and human studies have investigated the mechanisms involved in PE biological actions, including steroid hormone ac...

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Phytoestrogens after breast cancer.

The current extension of the indications for adjuvant chemotherapy, which predisposes to early menopause, and the media coverage of the benefits of hormone replacement therapy (HRT) have led patients with a history of breast cancer to seek treatments for estrogen deprivation. In breast cancer survivors, most physicians avoid HRT because of concern regarding the potential promotion of growth of ...

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Phytoestrogens and indicators of breast cancer prognosis.

Breast cancer incidence is lower and survival is longer in Asian women residing in Japan, China, or the Philippines than Caucasian women residing in the United States. Phytoestrogen intake has been examined as a possible reason for the disparity in breast cancer incidence and survival. This study examined the association between phytoestrogen intake prior to diagnosis of breast cancer and indic...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 2008

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.10538